Metabolism and Cancer Laboratory



Nearly half of all cancer patients suffer from weight loss due to the loss of adipose and skeletal muscle tissues, or cachexia. This progressive illness limits cancer therapy and decreases survival as well as impairs quality of life. Currently, there is no effective therapy to slow down or block cancer-associated wasting. Kır laboratory utilizes molecular biology approaches, primary cell culture techniques, mouse tumor models and human tissue samples to dissect molecular mechanisms behind tumor signaling to adipose and muscle tissues and identify novel molecular targets for anti-cachexia therapy. Current projects focus on the roles of tumor-derived factors in energy wasting and the importance of their signaling mechanisms in the etiology of cancer cachexia with the overarching goal of studying therapeutic blockade of these pathways, which may prevent wasting in cancer patients.