PUBLICATIONS
Domaniku A, Agca S, Toledo B, Sucuoglu M, Özen SD, Bilgic SN, Arabacı DH, Kashgari AE, Kir S. Activated Oncostatin M signaling drives cancer-associated skeletal muscle wasting. Cell reports. Medicine (2024). 2024.101498.
Özen SD, Kir S. Ectodysplasin A2 receptor signaling in skeletal muscle pathophysiology. Trends in Molecular Medicine (2024). 2024.02.002.
Agca S, Waraich AD, Bilgic SN, Sucuoglu M, Dag M, Dogan SA, Kir S. Tumor-induced alterations in single-nucleus transcriptome of atrophying muscles indicate enhanced protein degradation and reduced oxidative metabolism. bioRxiv (2023) 2023.10.26.564119. Manuscript in submission.
Domaniku A, Bilgic SN, Kir S. Muscle wasting: emerging pathways and potential drug targets. Trends Pharmacol Sci. (2023) 44:705-718.
Iresjö BM, Kir S, Lundholm K. Parathyroid hormone related protein (PTHrP) in patients with pancreatic carcinoma and overt signs of disease progression and host tissue wasting. Transl Oncol. (2023) 36:101752
Bilgic SN, Domaniku A, Toledo B, Agca S, Weber BZC, Arabaci DH, Ozornek Z, Lause P, Thissen JP, Loumaye A, Kir S. EDA2R-NIK signalling promotes muscle atrophy linked to cancer cachexia. Nature (2023) 617: 827-834.
Weber BZC, Arabaci DH, Kir S. Metabolic Reprogramming in Adipose Tissue During Cancer Cachexia. Frontiers in Oncology (2022) 12:848394.
Weber BZC, Agca S, Domaniku A, Bilgic SN, Arabaci DH, Kir S. Inhibition of epidermal growth factor receptor suppresses tumour parathyroid hormone-related protein expression and ameliorates cancer-associated cachexia. J Cachexia Sarcopenia Muscle (2022) 3:1582-1594.
Song W, Kir S, Hong S, Hu Y, Wang X, Binari R, Tang HW, Chung V, Banks AS, Spiegelman B, Perrimon N. Tumor-Derived Ligands Trigger Tumor Growth and Host Wasting via Differential MEK Activation. Developmental Cell (2019) 48: 277-286.
Fan Y, Hanai JI, Le PT, Bi R, Maridas D, DeMambro V, Figueroa CA, Kir S, Zhou X, Baron R, Mannstadt M, Baron R, Bronson RT, Horowitz MC, Wu JY, Belizikian JP, Martin JT, Dempster DW, Rosen CJ, Lanske B. Parathyroid hormone directs bone marrow mesenchymal cell fate. Cell Metabolism (2017) 25: 661-672.
Kir S, Spiegelman BM. Cachexia and brown fat: a burning issue in cancer. Trends in Cancer (2016) 2: 461-463.
Kir S, Komaba H, Garcia AP, Konstantinos E, Suh H, Lanske B, Hodin RA, Spiegelman BM. PTH/PTHrP receptor mediates cachexia in models of kidney failure and cancer. Cell Metabolism (2016) 23: 315-323.
Svensson KJ, Long JZ, Jedrychowski MP, Cohen P, Lo JC, Serag S, Kir S, Shinoda K, Tartaglia JA, Rao RR, Kajimura S, Gygi SP, Spiegelman BM. A secreted Slit2 fragment regulates adipose tissue thermogenesis and metabolic function. Cell Metabolism (2016) 23: 454-466.
Kir S, White JP, Kleiner S, Kazak L, Cohen P, Baracos VE, Spiegelman BM. Tumour-derived PTH-related protein triggers adipose tissue browning and cancer cachexia. Nature (2014) 513: 100-104.
Kir S, Zhang Y, Gerard RD, Kliewer SA, Mangelsdorf DJ. Nuclear receptors HNF4a and LRH-1 cooperate in regulating Cyp7a1 in vivo. Journal of Biological Chemistry (2012) 287: 41334-41.
Goetz R, Ohnishi M, Kir S, Kurosu H, Wang L, Pastor J, Ma J, Gai W, Kuro-O M, Razzaque MS, Mohammadi M. Conversion of a paracrine fibroblast growth factor into an endocrine fibroblast growth factor. Journal of Biological Chemistry (2012) 287: 29134-46.
Kir S, Kliewer SA, Mangelsdorf DJ. Roles of FGF19 in liver metabolism. Cold Spring Harb Symp Quant Biol (2011) 76:139-44.
Li T, Holmstrom SR, Kir S, Umetani M, Schmidt DR, Kliewer SA, Mangelsdorf DJ. The G protein-coupled bile acid receptor, TGR5, stimulates gallbladder filling. Molecular Endocrinology (2011) 25: 1066-71.
Kir S, Beddow SA, Samuel VT, Miller P, Previs SF, Suino-Powell K, Xu HE, Shulman GI, Kliewer SA, Mangelsdorf DJ. FGF19 as a postprandial, insulin-independent activator of hepatic protein and glycogen synthesis. Science (2011) 331: 1621-24.
Gur-Dedeoglu B, Konu O, Kir S, Ozturk AR, Bozkurt B, Ergul G, Yulug IG. A resampling-based meta-analysis for detection of differential gene expression in breast cancer. BMC Cancer (2008) 8: 396.
Chan EY, Kir S, Tooze SA. siRNA screening of the kinome identifies ULK1 as a multidomain modulator of autophagy. Journal of Biological Chemistry (2007) 282: 25464-74.